Mitigation of hydrodynamics related stress in bioreactors: a key for the scale-up of enzyme production by filamentous fungi
2018
Roque, Tamiris | Augier, Frédéric | Hardy, Nicolas | Ben Chaabane, Fadhel | Nienow, Alvin | Béal, Catherine
Different impellers and stirring conditions are compared at the bench scale in order to identify the relevant hydrodynamic stress parameter that correlates best with the process characteristics, morphology, broth rheology and growth rate as measured during the culture of the filamentous fungi, T. reesei, used for the production of cellulases. A modified Energy Dissipation Circulation Function (EDCF) was the most relevant stress parameter, and its use is validated to predict fairly accurately the same process characteristics in an industrial bioreactor, as well as enzyme production. The results are of great importance for the scale-up of cellulase production for bioethanol manufacture from lignocellulosic biomass.
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