A statistical approach for detecting genomic aberrations in heterogeneous tumor samples from single nucleotide polymorphism genotyping data.
2010
Yau, Christopher | Mouradov, Dmitri | Jorissen, Robert N | Colella, Stefano | Mirza, Ghazala | Steers, Graham | Harris, Adrian | Ragoussis, Jiannis | Sieber, Oliver | Holmes, Christopher C
We describe a statistical method for the characterization of genomic aberrations in single nucleotide polymorphism microarray data acquired from cancer genomes. Our approach allows us to model the joint effect of polyploidy, normal DNA contamination and intra-tumour heterogeneity within a single unified Bayesian framework. We demonstrate the efficacy of our method on numerous datasets including laboratory generated mixtures of normal-cancer cell lines and real primary tumours.
Afficher plus [+] Moins [-]Informations bibliographiques
Cette notice bibliographique a été fournie par National Institute for Agricultural Research
Découvrez la collection de ce fournisseur de données dans AGRIS