Efficacy of Thunbergia laurifolia (Rang Jued) aqueous leaf extract for specific biological activities using RAW 264.7 macrophage cells as test model
2017
Junsi, M. | Siripongvutikorn, S. | Takahashi Yupanqui, C. | Usawakesmanee, W.
Thunbergia laurifolia or Rang Jued (RJ) has been used in Thailand in folklore medicine since ancient times and has been claimed have anti-inflammatory, and antioxidant properties and to be an antidote for several toxins. The phytochemical screening, antioxidant and antiinflammatory activities including anti-dote of aqueous leaf extract on RAW 264.7 macrophage cells were evaluated. Data indicated that the extract contained phenols, flavonoids, tannins, sterols and cardiac-glycoside groups. Total extractable phenolic contents (TPC) and antioxidant activities of the extract were quite high level compared with other researches’ data. The high performance liquid chromatographic (HPLC) analysis of phenolics and flavonoids indicated the presence of pyrogallol, caffeic acid, rosmarinic acid and rutin compounds. The extract could not only reduce nitric oxide production but also increased cell proliferation and was judged as cytotoxicity even in low level. In addition, the extract could be used as preventing agent not for curing treatment for RAW 264.7 macrophage cells treated with cadmium (Cd) and chlorpyrifos (CP). However, preventing efficacy of the extract to CP toxicity was higher compared with Cd.
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