Effect of germination on antioxidant, anti-inflammatory and keratinocyte proliferation of rice
2016
Vichit, W. | Saewan, N.
The aim of this study was to investigate the impact of germination on the amount of bioactive compound, antioxidant, anti-inflammatory and keratinocyte proliferation of three rice varieties:one non-pigmented rice (Hom mali 105; HM) and two pigmented rice (Mun pu; MP and Leum phua; LP rice). The phenolic and procyanidin content were evaluated and the antioxidant activities were investigated using FRAP, DPPH and SOD assays. Germinated rice showed a trend for higher amounts of bioactive compounds and antioxidant activities than ungerminated rice. The highest phenolic content was found in germinated Leum phua (LP-G) rice extract (0.11±0.00 mg GAE/ml extract). While germinated Mun pu (MP-G) rice extract showed the highest procyanidin content with 0.13±0.00 mg CE/ml extract. LP-G rice extract had the highest activities with FRAP (0.51±0.01 mg AAE/ml extract) and DPPH (70.97±1.15%) aswell as increased enzymatic antioxidant SOD activity (51.40±1.07%). The potential antiinflammation and cell proliferation promoting of the extracts were investigated on normal adult human primary epidermal keratinocyte cells (NHEK). LP-G extract exhibited the best keratinocyte proliferation promoting (29.29±0.47%). Moreover, germinated rice extracts, especially pigmented rice (MP-G and LP-G) showed anti-inflammation activity by suppressing nitric oxide production. The results revealed that the germinated rice extracts can be used as a natural source of bioactive compound with antioxidant, anti-inflammation and keratinocytes’ proliferation properties which high potential for use in cosmetics, functional foods and pharmaceuticals.
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