Gold complexes as potential supplements with anticancer and antiviral action | Кompleksi zlata kao potencijalni suplementi sa antikancerogenim i antivirusnim delovanjem
2021
Antonijević, Marko | Đorović Jovanović, Jelena | Kesić, Ana | Milenković, Dejan | Marković, Zoran
The pharmacologic properties of gold compounds have been known since theend of the 19th century. They have been used for different studies, even thoughthey are usually used for the treatment of arthritis. In the last decade, goldcomplexes have received increased attention due to the variety of theirapplications. Primary, they have been investigated as potential anticancer andchemotherapeutic agents. It is well known that gold(III) complexes are very similarto platinum(II) compounds, so they could exhibit prospective anticancer, cytotoxicand antitumor properties.In this paper, were investigated the interactions of the gold(III) complexes,[Au(DPP)Cl2]+ and [Au(DMP)Cl3] where DPP=4,7-diphenyl-1,10-phenanthrolineand DMP=2,9-dimethyl-1,10-phenanthroline) with SARS-CoV2 protease. Theobtained results indicate that the square-planar [Au(DPP)Cl2]+ complex showsgood inhibitory activity, compared to FDA approved drugs, cinanserin andchloroquine.
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