Dietary supplementation of nano-selenium eliminates the negative effects of long-term ivermectin injection on growth and reproductive performance of female rabbits
2022
Set A. El-Shobokshy (Department of Nutrition and Veterinary Clinical Nutrition, Faculty of Veterinary Medicine, Alexandria University, Alexandria, Egypt) | Magda Ismail Abo-Samaha (Poultry Breeding and Production, Department of Animal Husbandry and Animal Wealth Development, Faculty of Veterinary Medicine, Alexandria University, Alexandria, Egypt) | Samia Mohamed Abd El-Rheem (Theriogenology Department, Faculty of Veterinary Medicine, Alexandria University, Alexandria, Egypt) | Ferial Mohamed Sahwan (Animal Breeding and Production, Department of Animal Husbandry and Animal Wealth Development, Faculty of Veterinary Medicine, Alexandria University, Alexandria, Egypt) | Gemechu Wirtu (Department of Biomedical Sciences, College of Veterinary Medicine, Tuskegee University, Tuskegee, AL, USA) | Mosaad Abdel Khalek Soltan (Department of Nutrition and Veterinary Clinical Nutrition, Faculty of Veterinary Medicine, Alexandria University, Alexandria, Egypt) | Mohamed Emam (Department of Nutrition and Veterinary Clinical Nutrition, Damanhour University, Damanhour, Egypt.)
Objective: We investigated the effects of a source of selenium [inorganic or nano-selenium (nano-Se)] on female V-line rabbits with or without injection of ivermectin (IVM). Material and Methods: Eighty four rabbits (12 weeks old) were randomly divided into 4 groups of 21 rabbits each with the basal diet supplemented as per the following treatments: G1 (control): inorganic Se at 0.3 mg/kg diet with no IVM injection; G2: inorganic Se with IVM injection; G3: nano-Se with no IVM injection; and G4: nano-Se with IVM injection. IVM was injected subcutane¬ously at 0.2 mg/kg body weight starting when the does were 14 weeks old and repeated weekly for five consecutive weeks. Results: Replacement of inorganic Se with nano-Se improved body weight and total body weight gain, total feed intake, average feed conversion ratio, and reproductive performance (age at puberty, number of service/conception, conception rate, number of kits/litter, and lit¬ter weight at birth). Similarly, sexual activity of does, serum estrogen levels, and serum levels of antioxidants (glutathione reduced, catalase, and malondialdehyde) increased in nano-Se-sup¬plemented groups. Ivermectin treatment in inorganic Se-supplemented groups was detrimental to growth and reproductive performance, while these parameters improved in IVM-treated and nano-Se-supplemented groups. Conclusion: Nano-Se mitigated the negative effects of IVM treatment on the growth and repro¬ductive performance of does. [J Adv Vet Anim Res 2022; 9(1.000): 128-137]
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