Protective immunity against equine herpesvirus type-1 infection following immunisation of mice with a non-pathogenic equine herpesvirus type-4
1999
Mohd Azmi M. L.
Protection against equine herpesvirus type-1 (EHV-1) infection was studied in mice following immunisation with its related heterologous virus EHV-4. The EHV was found to be non-pathogenic in mice. Inoculation of mice with either live or heat-inactivated EHV-4 stimulated IgG antibody response to both EHV-4 and EHV-1 antigens. Similar cross-reactive phenomenon was observed in mice inoculated with EHV-1. A significant level of virus-specific antibody was detected when the hyperimmune sera were tested by the virus neutralisation assay but not by ELISA. Antibody production following inoculation of mice either with live or heat-inactivated EHV were generally at similar levels. Hhowever, when mice were challenged with EHV-1, protection was only observed in mice immunised with live EHV-4. It is thus suggested that live EHV-4 can induce protective immunity against severe disease of EHV-1 and could possibly be used as an immunising agent to stimulate protective immunity against heterologous virus, EHV-1.
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