Chronic toxicity studies of feed additive “T-1.4”

Introduction. Of significant interest is the support of the poultry body through the use of new generation feed additives that increase productivity and reduce poultry mortality and disease in changing production conditions and the metabolic response of poultry. At the same time, the general toxic properties of new feed additives should be studied. The purpose of the research was to study the chronic toxicity of the feed additive “T-1.4”. Materials and methods. The study of chronic toxicity was carried out on male and female non-linear white rats. The feed additive for laying hens was tested by using it with drinking water in previously established optimal doses (minimum and maximum – 0.02 and 0.05 % solutions and ten times higher than it – 0.2 %. Experimental groups: the first group – 0.2 % solution (18 females and 18 males); the second group – 0.05 % solution (18 females and 18 males); the third group – 0.02 % solution (18 females and 18 males); the fourth group − the control (intact) group (18 females and 18 males).The total duration of observation was 90 days. They were 60 days of daily administration of the feed additive and 30 days of post-observation. Research results, discussion. It was found that the feed additive “T-1.4” in the recommended and tenfold recommended dose does not have a pronounced toxic effect. The use of the feed additive did not have a negative effect on the general condition of the animals, as well as on body weight gain, hematological blood parameters, biochemical parameters of blood serum. Necropsy demonstrated that supplementation at the recommended doses (0.02−0.05 %) did not cause visible changes in internal organs and in organ mass ratios in animals. The additive does not have a local irritating effect at the administration site (gastric mucosa). Conclusion. The new feed additive for laying hens “T-1.4” in the recommended doses does not have a negative effect on laboratory animals and can be further tested on laying hens.