Pharmacokinetic characteristics of the drug based on moxidectin for young stock and small breed of domestic animals
2020
Belykh, Irina P.
The pharmacokinetic characteristics of moxidectin in the blood serum of dogs and cats after a single cutaneous (spot-on) application of drug for veterinary use "Inspector Mini" to prevent and treat arachnoses, entomoses and intestinal nematodes in kittens and puppies as well as in small breed dogs and cats were investigated. Twelve outbred dogs and cats of different ages and weights were involved in present study. All the animals were weighed to determine the exact dosage of the drug. The determination of moxidectin in blood serum was carried out by high performance liquid chromatography with pre-column modification of N-methylimidazole and trifluoroacetic anhydride followed by fluorescence detection. According to the results of the study, it was found that moxidectin was well absorbed into the systemic circulation and reached to maximum concentration in the blood serum of dogs and cats after 4-10 days. After treatment with the drug, moxidectin was determined in the blood serum of animals after 12 hours at concentration of 2 ng/ml. Significant concentrations of moxidectin in the blood serum of animals remained for 28 days after topical application (spot-on). Moxidectin was detected in the blood serum of animals at the end of the experiment (after 30 days) which indicates its therapeutic effect for at least one month after the application of the drug.
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