Gastroprotection and prostaglandin E2 generation in rats by flavonoids of Dittrichia viscosa
1993
Lastra, C.A. de la (Departamento de Farmacia y Tecnologia Farmaceutica, Sevilla (Spain). Facultad de Farmacia. Lab. de Farmacodinamia) | Lopez, A. | Motilva, V.
Investigations were carried out to determine the gastroprotective effects of the flavonoid fraction of Dittrichia viscosa (L.) W. Greuter against gastric lesions produced by necrotizing agents. The action of the fraction on the production of mucus, and the in- volvement of endogenous PGs in gastric mucosal defensive mechanisms were also determined. Gastric ulcers induced by oral administration of three necrotic agents (100% ethanol, 0.6N HCl, 30% NaCl) were markedly reduced by pretreatment with the flavonoid extract at doses from 125 to 500mg/kg p.o. and the reduction at the highest dose (500mg/kg p.o.) was practically complete. Flavonoid fraction pretreatment also increased mucus production and glycoprotein content. In addition, intraperitoneal administration of indo- methacin (10mg/kg i.p. ) to animals treated with the extract (500mg/kg) partially inhibited gastric protection but the PGE2 determination did not show an increase in prostanoid level. These observations suggest that the gastroprotective effects of the flavonoid fraction from D. viscosa could be partly explained through non-prostaglandin-dependent mechanisms.
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