Detection of reserpine in horses by high-performance liquid chromatography
1991
Chapman, C.B. | Courage, P. (Victorian College of Pharmacy Ltd, Parkville (Australia)) | Huntington, P.J. (Victorian Dept. of Agriculture and Rural Affairs, Attwood (Australia). Victorian Inst. of Animal Science)
An assay was developed to detect reserpine and was subsequently used to monitor the plasma concentrations of the drug given intramuscularly to 5 horses. Reserpine could be detected and quantified for 48 hours after a single dose of 2.5 mg, and for a similar period after the second of two 2.5 mg doses given 13 d apart. Because of the apparently large variability in the pharmokinetics, exact times could not be given beyond which the drug would no longer be detectable in the plasma. However, following 2 doses of 2.5 mg given 13 days apart, at least 7 days must elapse after the second dose before there is no drug detectable in the plasma of most horses.
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