Development of a vaccine preventing parvovirus-induced reproductive failure in pigs [porcine parvovirus]
1990
Pye, D. | Bates, J. | Edwards, S.J. | Hollingworth, J. (Commonwealth Serum Lab., Parkville (Australia))
An inactivated porcine parvovirus (PPV) vaccine for the prevention of PPV-induced reproductive failure in pigs was developed, using virus grown in cell culture, inactivated with beta-propiolactone and adjuvanted with aluminium hydroxide. The vaccine was tested for safety by subcutaneous injection into pregnant gilts. There were no signs of abnormal reactions nor evidence of PPV infection in the gilts or their foetuses when they were sacrificed 6 weeks after vaccination. Vaccination of pigs with the vaccine demonstrated that it was immunogenic and protective, and therefore effective in preventing PPV reproductive failure in susceptible gilts.
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