Experimental chronic intoxication of chickens with polychlorinated biphenyls (Delor 103)
1993
Halouzka, R. (Vysoka Skola Veterinarni a Farmaceuticka, Brno (Czech Republic). Katedra Patologicke Morfologie) | Jurajda, V. | Vavrova, M.
The effect of long-term intake of feed contaminated with polychlorinated biphenyls (PCB) in the form of Delor 103, a technical preparation (42 % chlorine), on the dynamics of development of the morphological changes in the organs of chickens was investigated in an in-vivo experiment. Brown Hisex layer hybrid cockerels from a commercial flock were fed a feed mixture contaminated with Delor 3 in dosed of 25 mg.kg-1 from 1 day to 10 weeks of age. At 2 weeks intervals they were weighed and sacrificed and relative mass of the bursa of Fabricius and spleen was determined. The lymphoid organs, liver, kidney, caecal valve, Harder's gland, oesophagus, gonads, skin and other grossly changed organs were subjected to histological examination. In evaluating the bursa of Fabricius, thymus and spleen use was also made of semiquantitative criteria. Pooled samples of the pectoral muscle were analysed for PCB content. The alterations in the clinical status, body growth and relative mass of the bursa of Fabricius and spleen correlated with the dose level. Even the lower dose produced lymphocytotoxic, hepatotoxic and vascularotoxic effects. The changes observed at the end of the experiment corresponded to chronic intoxication with PCB. Of interest were the findings of adenoma of the pancreas and mainly dystrophic lesions in the central and peripheral nervous system.
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