Clinical features of ceroid lipofuscinosis in Border Collie dogs [congenital nervous storage disease]
1991
Studdert, V.P. | Mitten, R.W. (Melbourne Univ., Werribee (Australia). Veterinary Clinical Centre)
Ceroid lipofuscinosis was diagnosed by histopathological and histochemical findings in 17 related dogs and by clinical signs in 6 of their litter mates. Behavioural changes, first hyperactivity and later aggression, commenced at 16 to 23 months of age. Motor abnormalities and blindness were observed at the mean age of about 21 months. All dogs were euthanased 1 to 6 months after the onset of clinical signs, mean age about 23 months. Pedigree data supported an autosomal recessive mode of inheritance.
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