Biologically active triterpene saponins from Bupleurum fruticosum
1994
Guinea, M.C. | Parellada, J. | Lacaille-Dubois, M.A. | Wagner, H. (Alcala de Henares Univ., Madrid (Spain). Dept. de Farmacia y Tecnologia Farmaceutica)
Extracts of the root of Bupleurum fruticosum L. showed in a biological screening hemolytical activity, hepatoprotective and phagocytosis stimulating effects, and a specific inhibitory activity of leucine aminopeptidase. Further monitoring of the fraction with antihepatotoxic activity led to the isolation of an hepatoprotective saikosaponin identified as buddlejasaponin 4 and the new malonylbuddlejasaponin 4, determined as saikogenin. The structures were elucidated on the basis of the chemical and spectroscopic data.
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