Biological activities of cyanobacteria: evaluation of extracts and pure compounds
1995
Falch, B.S. | Koenig, G.M. | Wright, A.D. | Sticher, O. | Angerhofer, C.K. | Pezzuto, J.M. | Bachmann, H. (Eidgenoessisch Technische Hochschule, Zuerich (Switzerland). Dept. of Pharmacy)
A total of 80 lipophilic and hydrophilic extracts obtained from 20 samples of cultured freshwater and terrestrial cyanobacteria were investigated for their biological activities. Of all the extracts, 26% exhibited a significant lethal effect against brine shrimp. Out of 54 extracts tested for antimicrobial activity, 78% showed antibacterial and 45% antifungal activities. Of 30 extracts tested for cytotoxicity against KB cells, none was found to be active. Bioassay-guided fractionation of the lipophilic extracts of Fischerella ambigua led to the isolation of three compounds; ambigols A 1. and B 2. and tjipanazole D 3. Compounds 1 and 2 exhibited antibacterial, antifungal, cytotoxic, molluscicidal, anti-inflammatory, and antiviral activities. Tjipanazole D 3 showed moderate antibacterial properties.
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