Antimutagens and anticarcinogens in foods
2001
Filipic, M. (National Inst. of Biology, Ljubljana (Slovenia))
Three major factors for human carcinogenesis are (i) cigarette smoking, (ii) infection and inflammation and (iii) nutrition and dietary factors. Nutrition and dietary factors include two categories of factors influencing cancer development, namely genotoxic agents implicated in tumor initiation and constituents implicated in tumor promotion and progression. Nutritional factors on the other hand play a major role in cancer prevention. Fruits and vegetables contain different substances, which were proven to prevent cancer development at diffenet stages. Those include vitamins, carotens and non-nutritive components like flavonoids, phenoles, indoles, phytosterols, glucosinolates etc. Nutrition and dietary condition together with supplementation of chemopreventive agents will eventually lead us to cancer prevention, namely delay of onset of cancer to the late phase of human life, which is called 'natural-end cancer'.
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