Prediction of additive genetic effect for the QTL-cluster on the basis of data on surrounding markers in outbred populations
2002
Matsuda, H. | Iwaisaki, H. (Graduate School of Science and Technology, Niigata (Japan). Course of Environmental Management Science)
The paper described a method for predicting additive effects of a cluster of tightly linked QTLs for outbred populations of animals in the situation where the QTLs are located on a chromosome segment surrounded by multiple linked DNA markers. The authors present a mixed model method for best linear unbiased prediction of the additive effects of the QTL-cluster and of remaining QTLs unlinked to the marker linkage group. This method takes into consideration the identity-by-descent proportion for the particular chromosomal segment, in contrast to some other methods which use IBD probabilities at one specific location
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