Synergistic activity of plant prebiotics and Lactococcus lactis KA-FF 1-4 to enhance vancomycin-resistant enterococci (VRE) growth inhibition
2020
Pongsuwanporn, T. | Udomsri, P. | Nitisinprasert, S. | Nakphaichit, M.
Synbiotics are products containing both probiotics and prebiotics, in which the prebiotic compound selectively favours the probiotic to provide synergistic activity for gut health promotion. Due to its potential probiotic effect, Lactococcus lactis KA-FF 1-4 showed inhibitory activity against vancomycin-resistant enterococci (VRE). Its synergistic activity with three commercial plant prebiotics namely inulin, fibersol-2, and XOS is presented in the present work. In vitro batch fermentation with each prebiotic supplement had no effect on the growth rate of L. lactis KA-FF 1-4. However, supplementation with either 2% w/v inulin or fibersol-2 dramatically enhanced anti-VRE activity. Further study was performed on the effect of various concentrations (0.5, 1, 2, and 5%) of inulin or fibersol-2 on anti-VRE activity. In co-culture, L. lactis KA-FF 1-4 with 1% inulin supplementation could apparently reduce the VRE concentration from log 4.0 to 2.7 CFU/mL after 12 h, while complete inhibition was observed with 2% fibersol-2 supplementation after 6 h. These results clearly showed the synergistic effect on VRE growth inhibition, which may serve as a guideline for the development of synbiotic formulations in the future.
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