HMG-CoA reductase and lipase enzyme inhibition from combination of Gynura procumbens and Curcuma xanthorrhiza aqueous extract
2021
Setyowati, E. | Ikawati, Z. | Hertiani, T. | Pramantara, I. D. P.
Lifestyle habits related to consuming excessive fatty foods lead to high levels of lipids in the blood. Some drugs are used to reduce lipids by inhibiting the action of the enzyme HMG-CoA reductase and the pancreatic lipase. The Curcuma xanthorrhiza rhizome and Gynura procumbens leaves were empirically used to reduce cholesterol and lipid levels. This study used the combination of aqueous extract of G. procumbens and C. xanthorrhiza rhizomes (4:1) and their single forms as herbs tested. Furthermore, this study aimed to determine the activity of the tested herbs in inhibiting the enzymatic actions of HMG-CoA reductase and pancreatic lipase in vitro, compared with quercetin, curcumin, and positive control. The results showed that the aqueous extract of C. xanthorrhiza with an IC₅₀ value of 127.54 ppm has the highest activity in inhibiting the enzyme HMG-CoA reductase compared to the aqueous extract of G. procumbens and their combination. In the inhibition of lipase enzyme, G. procumbens aqueous extract had the most potent inhibitory activity compared to C. xanthorrhiza and their combination with an IC50 value of 100.08 ppm
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