Omics biomarkers and an approach for their practical implementation to delineate health status for personalized nutrition strategies
2023
Keijer, Jaap | Escoté, Xavier | Galmés, Sebastià | Palou-March, Andreu | Serra, Francisca | Aldubayan, Mona Adnan | Pigsborg, Kristina | Magkos, Faidon | Baker, Ella J. | Calder, Philip C. | Góralska, Joanna | Razny, Urszula | Malczewska-Malec, Malgorzata | Suñol, David | Galofré, Mar | Rodríguez, Miguel A. | Canela, Núria | Malcic, Radu G. | Bosch, Montserrat | Favari, Claudia | Mena, Pedro | Del Rio, Daniele | Caimari, Antoni | Gutierrez, Biotza | del Bas, Josep M.
Personalized nutrition (PN) has gained much attention as a tool for empowerment of consumers to promote changes in dietary behavior, optimizing health status and preventing diet related diseases. Generalized implementation of PN faces different obstacles, one of the most relevant being metabolic characterization of the individual. Although omics technologies allow for assessment the dynamics of metabolism with unprecedented detail, its translatability as affordable and simple PN protocols is still difficult due to the complexity of metabolic regulation and to different technical and economical constrains. In this work, we propose a conceptual framework that considers the dysregulation of a few overarching processes, namely Carbohydrate metabolism, lipid metabolism, inflammation, oxidative stress and microbiota-derived metabolites, as the basis of the onset of several non-communicable diseases. These processes can be assessed and characterized by specific sets of proteomic, metabolomic and genetic markers that minimize operational constrains and maximize the information obtained at the individual level. Current machine learning and data analysis methodologies allow the development of algorithms to integrate omics and genetic markers. Reduction of dimensionality of variables facilitates the implementation of omics and genetic information in digital tools. This framework is exemplified by presenting the EU-Funded project PREVENTOMICS as a use case.
Afficher plus [+] Moins [-]Mots clés AGROVOC
Informations bibliographiques
Cette notice bibliographique a été fournie par Wageningen University & Research
Découvrez la collection de ce fournisseur de données dans AGRIS