Sesquiterpenoids from the Stem Bark of Aglaia grandis
2022
Desi, H. | Kindi, F. | Unang, S. | Mohamad, N.A. | Yoshihito, S. | Atika, A.P. | Amallya, A. | Al, A.N. | Sari, N. | Tri, M. | Rani, M. | Agus, S. | Ace, T.H.
Five sesquiterpenoids, 7-epi-eudesm-4(15)-ene,1β,6α-diol (1), 7-epi-eudesm-4(15)-ene,1β,6α-diol (2), saniculamoid D (3), aphanamol I (4), and 4β,10α-dihydroxyaromadendrane (5), were isolated from the stem bark of Aglaia grandis. The compounds’ (1-5) chemical structures were identified by spectroscopic data including, IR, NMR (¹H, ¹³C, DEPT 135°, HMQC, HMBC, ¹H-¹H COSY), and HRTOFMS, as well as by comparing with the previously reported spectral data. Therefore, this study described the structural elucidation of compounds 1-5 and evaluated their cytotoxic effects against Hela cervical and B16F10 melanoma cells for the first time, but no significant result was discovered.
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