Topical application of silymarin enhances cutaneous wound healing in rats
2019
Tabari, S.A. | Carpi, S. | Polini, B. | Nieri, P. | Esfahani, M.L. | Moghadamnia, A.A. | Ghorbani, H. | Ranaei, M. | Kazemi, S.
Wound healing in a short period with minimum side effects is one of the major goals of medical sciences. Silymarin, an extract from Silybum marianum, has been shown to have antioxidant and anti-inflammatory properties. This study investigates the wound healing activity of silymarin topical formulation in an in experimental model.A 875 mm2 (25 × 35 mm) full-thickness excision was made on the abdominal region of each rat by a surgical blade and the day on which the wound was made considered as day 0. Each rat was treated two times each day. On days 1,4, 8 and 12, the wound area was measured using precise caliber and camera imaging. On day 12, blood samples were collected for the analysis of antioxidant, malondialdehyde and estradiol levels. After 12 days of treatment, rats were sacrificed and abdominal region tissues used for histological analyses.The study showed that topical application of silymarin on wound in rats improved wound healing correlating with less redness, exudates and swelling. Furthermore, in serum of rats treated with silymarin ointment improved antioxidant and estradiol levels, while decreased malondialdehyde levels, a marker of oxidative stress. Histological analyses showed also an improve of novel blood vessels. This effect on angiogenesis correlated with improve nitric oxide synthase expression and epithelial cells after treatment with silymarin.Silymarin ointment represents a promising therapeutic agent for the treatment of wounds through its antioxidant and anti-inflammatory properties.
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