Electrochemical Difunctionalization of Terminal Alkynes: Access to 1,4-Dicarbonyl Compounds
2021
Hu, Jingcheng | Zeng, Li | Hu, Jiayu | Ma, Rui | Liu, Xue | Jiao, Ying | He, Haoyu | Chen, Siyu | Xu, Zhexi | Wang, Hongfei | Lei, Aiwen
1,4-Dicarbonyl compounds are versatile scaffolds for the heterocycle synthesis, including the Paal–Knorr reaction. Herein, a feasible electrosynthesis method to access 1,4-dicarbonyl compounds has been developed from simple alkynes and 1,3-dicarbonyl compounds. When the undivided cell is combined with the constant current mode, aryl alkynes containing numerous medicinal motifs with 1,3-dicarbonyl esters or ketones react smoothly. External oxidant and catalyst-free conditions conform to the requirements of green synthesis.
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