A new synthesis of indoles via intramolecular cyclization of ο-alkynyl N,N-dialkylanilines promoted by KOt-Bu/DMSO
2015
Chen, Yan-yan | Chen, Jia-hua | Zhang, Niu-niu | Ye, Lin-miao | Zhang, Xue-Jing | Yan, Ming
2-Aryl indoles could be prepared in excellent yields via the intramolecular cyclization of ο-alkynyl N,N-dialkylanilines. The reaction is efficiently promoted by the catalytic amount of KOt-Bu in DMSO at room temperature. A reaction mechanism involving α-aminoalkyl radical intermediates is suggested.
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