The effect of Hypericum perforatum on isolated rat aorta
2011
Tugrul, Ibrahim | Demirci, Buket | Demir, Ömer | Dost, Turhan | Birincioglu, Mustafa
Context: Different Hypericum species such as Hypericum perforatum (HP) L. and Hypericum triquetrifolium Turra are well known and widely used traditional medicine in Turkey. Objectives: We investigated the effect of standardized HP extract on endothelium and vascular function. Materials and methods: After suspending the aortas with endothelium in organ baths containing Krebs solution, contractile and relaxant responses were assessed in the absence and presence of HP (0.05 mg/ml). Results: Although there were significant reductions in the contractile responses to phenylephrine (1113.73+/- 164.11; 477.40+/- 39.94; p < 0.05) and potassium chloride (745.58 +/- 66.73; 112.58 +/- 26.58; p < 0.05), no differences in the relaxant responses to acetylcholine (94.61 +/- 2.65; 87.79 +/-9.40) and sodium nitroprusside (108.82 +/- 5.06; 106.43 +/- 7.45) were observed. Discussion and conclusion: These data suggest that even the high dose of HP intervention does not bring any harmful effect on endothelium and smooth muscle function; meanwhile it might be beneficial on some of diseases accompanied with increased vascular contraction.
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