Click and Release: A High-Content Bioorthogonal Prodrug with Multiple Outputs
2019
Ji, Xingyue | Aghoghovbia, Robert E. | De La Cruz, Ladie Kimberly C. | Pan, Zhixiang | Yang, Xiaoxiao | Yu, Bingchen | Wang, Binghe
A high-content bioorthogonal prodrug with multiple outputs using the “click, cyclize, and release” concept is described. The proof of concept is established by the co-delivery of a gasotransmitter carbon monoxide, an anticancer drug floxuridine, and an in situ generated fluorescent reporter molecule for real-time monitoring of the prodrug activation. Bioorthogonal prodrugs as such are invaluable tools for the co-delivery of other drug payloads for multimodal therapy.
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