Palladium(II)-Catalyzed Tandem Cyclization/C–H Functionalization of Alkynes for the Synthesis of Functionalized Indoles
2012
Xia, Xiao-Feng | Wang, Ning | Zhang, Lu−Lu | Song, Xian-Rong | Liu, Xue-Yuan | Liang, Yong-Min
A palladium-catalyzed tandem cyclization/C–H functionalization of two alkynes was accomplished to construct a series of polycyclic functionalized indoles. A range of internal alkynes bearing synthetically useful functional groups were tolerated. A good regioselectivity was observed when alkyl-substituted alkynes were introduced into the reaction system, and a single product was obtained. Molecular oxygen was used as the terminal oxidant in the approach, rendering the reaction more sustainable.
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