Pharmacokinetics and synovial fluid concentrations of cephapirin in calves with suppurative arthritis

Brown, M.P.; Gronwall, R.R.; Pattio, N.; Poulos, P.W.; Houston, A.E.

Pharmacokinetics and synovial fluid concentrations of cephapirin in calves with suppurative arthritis

1991

Brown, M.P. | Gronwall, R.R. | Pattio, N. | Poulos, P.W. | Houston, A.E.

Six calves with suppurative arthritis were given a single IM injection of sodium cephapirin at a dosage of 10 mg/kg of body weight. Cephapirin concentrations were serially measured in serum and in normal and suppurative synovial fluid over a 24-hour period. Mean peak serum concentration was 6.33 microliter/ml at 20 minutes after injection. The highest cephapirin concentrations in normal and suppurative synovial fluid were 1.68 and 1.96 microgram/ml, respectively, 30 minutes after injection. Overall mean cephapirin concentration in normal synovial fluid for the first 4 hours (1.04 +/- 0.612 microgram/ml) was not significantly different from that in suppurative synovial fluid (0.88 +/- 0.495 microgram/ml; P > 0.05). Elimination half-life was 0.60 hours and clearance was 1,593 ml/h/kg.

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