A new predictive equation for resting energy expenditure in healthy individuals
1990
Mifflin, M.D. | St Jeor, S.T. | Hill, L.A. | Scott, B.J. | Daugherty, S.A. | Koh, Y.O.
A predictive equation for resting energy expenditure (REE) was derived from data from 498 healthy subjects, including females (n = 247) and males (n = 251), aged 19-78 y (45 +/- 14 y, average +/- SD). Normal-weight (n = 264) and obese (n = 234) individuals were studied and REE was measured by indirect calorimetry. Multiple-regression analyses were employed to derive relationships between REE and weight, height, and age for both men and women (R2 = 0.71): REE = 9.99 X weight + 6.25 X height - 4.92 X age + 166 X sex (males, 1; females, 0) - 161. Simplification of this formula and separation by sex did not affect its predictive value: REE (males) = 10 X weight (kg) + 6.25 X height (cm) - 5 X age (y) + 5; REE (females) = 10 X weight (kg) + 6.25 X height (cm) - 5 X age (y) - 161. The inclusion of relative body weight and body-weight distribution did not significantly improve the predictive value of these equations. The Harris-Benedict Equations derived in 1919 overestimated measured REE by 5% (p less than 0.01). Fat-free mass (FFM) was the best single predictor of REE (R2 = 0.64): REE = 19.7 X FFM + 413. Weight also was closely correlated with REE (R2 = 0.56): REE = 15.1 X weight + 371.
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