Antihypertensive Agents in Patients With Diabetes
2006
Navaneethan, Sankar D. | Querques, Marialuisa | Bonifati, Carmen | Strippoli, Giovanni F. M.
Purpose Management of hypertension in patients with diabetes should address both renal and cardiovascular protection. The use of angiotensin-converting enzyme(ACE) inhibitors and angiotensin II receptor blockers (ARBs) for control of hypertension in patients with diabetic nephropathy is widely advocated by various international guidelines. Use of any agent that provides tight control of blood pressure is indicated in patients with diabetes but without nephropathy. Methods In this article, the authors present a clinical case scenario and review current clinical evidence supporting the use of ACE inhibitors and ARBs inpatients with diabetic nephropathy. In addition, the use of ACE and ARBs inpatients with diabetes but without nephropathy will be discussed. Results Available trial evidence confirms the survival benefits of patients taking ACE inhibitors with diabetic nephropathy. However, the efficacy of ARB inhibitors on survival is unknown. In patients with diabetes without nephropathy, only ACE inhibitors have been found to reduce the risk of onset of microalbuminuria, while all agents affect survival provided a tight control of blood pressure is monitored. Conclusions Dose of ACE inhibitors should be titrated appropriately to obtain proven benefits. In summary, current evidence supports the use of ACE inhibitors in patients with and without nephropathy because of renal and cardiovascular benefits.
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