Gd³⁺ cFLFLFK conjugate for MRI: a targeted contrast agent for FPR1 in inflammation
2012
Stasiuk, Graeme J. | Smith, Helen | Wylezinska-Arridge, Marzena | Tremoleda, Jordi L. | Trigg, William | Luthra, Sajinder Kaur | Iveson, Veronique Morisson | Gavins, Felicity N. E. | Long, Nicholas J.
Formyl Peptide Receptors (FPRs) are vital in the host inflammatory response, playing an important regulatory role in multiple diseases. A Gd(iii) DOTA conjugate of cFLFLFK has been synthesised which targets and visualises FPR1 upon leukocytes in the inflammatory response via magnetic resonance imaging for the first time.
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