Przewalskone: a cytotoxic adduct of a danshenol type terpenoid and an icetexane diterpenoid via hetero-Diels–Alder reaction from Salvia przewalskii
2012
Xu, Gang | Yang, Xing-Wei | Wu, Chun-Yan | Li, Xiao-Nian | Su, Jia | Deng, Xu | Li, Yan | Qin, Hong-Bo | Yang, Li-Xin | Zhao, Qin-Shi
Przewalskone (1), an unprecedented adduct of two different terpenoid units via a hetero-Diels–Alder cycloaddition, was isolated from the roots of Salvia przewalskii. The structure and absolute configurations were elucidated by extensive analysis of NMR spectra and crystal X-ray diffractions. Compound 1 exhibited significant cytotoxicities against five human cancer lines in vitro (IC₅₀ 0.69–2.35 μM).
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