Total synthesis of penta-Me amurensin H and diptoindonesin G featuring a Rh-catalyzed carboacylation/aromatization cascade enabled by CC activation
2019
Qin, Yuting | Zhan, Jun-Ling | Shan, Tian-tian | Xu, Tao
Oligostilbenoids represented a family of natural products, which contained one or several multifused benzofuran substructures and displayed promising biological activities towards cancer as well as immunological therapeutic targets. A convergent-divergent strategy featuring Rh-catalyzed carboacylation/aromatization cascade reaction based on CC activation of benzocyclbutenones had been conceived. penta-Methyl amurensin H and diptoindolnesin G were successfully synthesized without any protecting groups, constituting a new entry towards oligostilbenoids’ natural product synthesis. The synthesis completed within 10 steps for both natural products, suggesting conciseness and efficacy of the CC activation in complex natural product synthesis.
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