Xanthones inhibitors of α-glucosidase and glycation from Garcinia nobilis
2012
Fouotsa, Hugues | Lannang, Alain Meli | Mbazoa, Celine Djama | Rasheed, Saima | Marasini, Bishnu P. | Ali, Zulfiqar | Devkota, Krishna Prasad | Kengfack, Augustin Ephrem | Shaheen, Farzana | Choudhary, Muhammad Iqbal | Sewald, Norbert
One new xanthone, caroxanthone (1) together with six known xanthones, 4-prenyl-2-(3,7-dimethyl-2,6-octadienyl)-1,3,5,8-tetrahydroxyxanthone (2), smeathxanthone A (3), gartanin (4), euxanthone (5), 8-hydroxycudraxanthone G (6) and morusignin I (7) were isolated from the stem bark of Garcinia nobilis. The structures were determined by 1D- and 2D-NMR techniques. All these compounds were tested for anti-glycation, α-glucosidase and α-chymotrypsin activities. Some of them exhibited strong to moderate α-glucosidase activities, while none of them inhibited α-chymotrypsin. Compounds 6 and 7 were found to be modest α-glucosidase inhibitors with IC₅₀ values of 76μM and 84μM, respectively.
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