Discovery of a ¹⁹F MRI sensitive salinomycin derivative with high cytotoxicity towards cancer cells
2016
Shi, Qiuyan | Li, Yu | Bo, Shaowei | Li, Xiaofei | Zhao, Peng | Liu, Qi | Yang, Zhigang | Cong, Hengjiang | Deng, Hexiang | Chen, Mingnan | Chen, Shizhen | Zhou, Xin | Ding, Hong | Jiang, Zhong-Xing
Salinomycin is a promising anti-cancer agent which selectively targets cancer stem cells. To improve its potency and selectivity, an analog library of salinomycin was generated by site-specific modification and CuAAc derivatization. Through a cytotoxicity analysis of the library, a fluorinated analog with high potency, selectivity, and ¹⁹F MRI sensitivity was discovered as a novel theranostic agent.
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