Effects of non-motorized voluntary running on experimental and spontaneous metastasis in mice
2011
Yan, Lin | Demars, Lana C
Physical activity is any form of movement using skeletal muscles. Human population and laboratory studies show that physical exercise may play a favorable role in primary cancer prevention.The present study investigated the effects of voluntary exercise on the development and growth of secondary cancer (the spread of malignant cells from a primary tumor to distant organs) in laboratory animals. On a voluntary basis, male mice ran an average of 4-6 km/day for the duration of the experiment (13 weeks). Voluntary exercise favorably decreased body weight, abdominal adiposity and the expression of related adipocytokines (e.g. insulin, leptin) in mice compared with the sedentary controls, but there were no differences in the number of tumors developed in the lungs. Interestingly, voluntary exercise significantly increased plasma concentration of platelet-derived growth factor, which plays a significant role in blood vessel formation, in tumor-bearing mice compared to their sedentary counterparts.In conclusion, voluntary running at 4-6 km/day did not affect the development and growth of secondary cancer in mice. Voluntary exercise-stimulated over-expression of platelet-derived growth factor in tumor-bearing animals warrants further investigation.
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