Fast Assembly and High-Throughput Screening of Structure and Antioxidant Relationship of Carotenoids
2019
Kim, Dahye | Shi, Gaosheng | Kim, YunJi | Koo, Sangho
C₂₀ heptaenyl diphosphonate 4 was prepared for one-pot synthesis of carotenoids 1. Olefination with various aromatic aldehydes allowed fast assembly of the corresponding carotenoids. The SAR of carotenoids was investigated by high-throughput screening of ABTS and DPPH assays and their hierarchical clustering analysis. Antioxidant activity of carotenoids increased with the number of electron-donating substituents. Carotene 1a with multiple electron-donating substituents was most proficient, which showed better radical scavenging activities than β-carotene and lycopene.
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