The ZrO2 NPs enhanced the risk of arsenate by promoting its accumulation and reducing its detoxification during food chain transfer from Daphnia magna to zebrafish
2022
Wang, Jiahui | Zhang, Jichao | Gao, Yan | Xiong, Haiyan | Zhang, Wei | Yan, Bing
Arsenic (As) can co-occur with zirconium dioxide nanoparticles (ZrO₂ NPs) in aquatic environments, but their combined influence along the aquatic food chain is barely explored. This study constructed water flea Daphnia magna – zebrafish Danio rerio to evaluate the impact of ZrO₂ NPs on the accumulation, trophic transfer, transformation, and detoxification of arsenate (As(V)). The zebrafish were fed D. magna exposed to As(V), ZrO₂ NPs, or As(V) + ZrO₂ NPs for 20 d. Results demonstrated that ZrO₂ NPs significantly facilitated total As and As(V) sorption in D. magna and in tissues of zebrafish. ZrO₂ NPs enhanced the transformation of inorganic arsenic (iAs) to monomethylated acid (MMA), while decreased synthesis of arsenobetaine (AsB) in tissues, leading to iAs increased. Co-exposed As(V) and ZrO₂ NPs facilitated upregulation of absorption-related genes (aqp7) and As biotransformation-related genes (gst, gss), and detoxification and oxidative stress-related genes (mt2, cat, sod1 and sod2). Therefore, genetic expression coupling with biotransformation for the first time demonstrated that As(V) combined with ZrO₂ NPs led to increased harm to D. magna and zebrafish and amplified the ecological risks of As(V) along the aquatic food chain. Attention should be paid to the combined toxicity of As(V) and ZrO₂ NPs in aquatic environment.
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