NK cell and macrophage activity in experimentally induced rabies in mice
2011
Shivasharanappa, N. | Singh, R. | Singh, K.P. | Madhu, B.P.
Twenty adult Swiss albino mice were intracerebrally inoculated with each 0.03ml of Challenge virus standard (CVS) strain of rabies virus. Similar amount of phosphate buffer saline was given intracerebrally to equal number of control mice. The NK cell and Macrophage profile studied by Fluorescent Activated Cell Sorting (FACS) using monoclonal antibodies revealed significantly higher activity of NK cells and macrophages in blood and spleen in rabies infected group than in control mice. All the infected mice could not survive and the lesions were characterized by infiltration of gitter cells in the hippocampus with perivascular cuffing suggesting that these cells played an important role in the pathogenesis of rabies.
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