Chemical constituents of Fumaria densiflora and the effects of some isolated spirobenzylisoquinoline alkaloids on murine isolated ileum and perfused heart
2020
Al-Ghazzawi, Adel M. | Abu Zarga, Musa H. | Abdalla, Shtaywy S.
Twenty-two alkaloids, were isolated from Fumaria densiflora. Two of these alkaloids, N-methyl-5-hydroxystylopine chloride and fumaricine N-oxide, were isolated for the first time from natural sources. Parfumine and fumaritine, in concentrations ranging from 3 × 10⁻⁷ to 9 × 10⁻⁴ M, caused concentration–dependent relaxation of ileum longitudinal segment. Also, parfumine and fumaritine in concentrations ranging from 3 × 10⁻⁴ to 9 × 10⁻² M, caused concentration – dependent decrease in heart rate of the isolated perfused heart. A concentration of parfumine of 3 × 10⁻² M increased but a higher concentration (9 × 10⁻² M) decreased the amplitude of contraction of the isolated perfused heart. On the other hand, fumaritine, in concentrations ranging from 3 × 10⁻⁴ to 3 × 10⁻² M, caused concentration – dependent increase, but a higher concentration (9 × 10⁻² M) caused a decrease in the amplitude of contraction of the isolated perfused heart.
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