Chitosan-Palmitic Acid Based Polymeric Micelles as Promising Carrier for Circumventing Pharmacokinetic and Drug Delivery Concerns of Tamoxifen
2017
Thotakura, Nagarani | Dadarwal, Mukesh | Rajendra Kumar, | Singh, Bhupinder | Sharma, Gajanand | Kumar, Pramod | Katare, Om Prakash | Raza, Kaisar
Being a BCS class II drug and a good substrate for microsomal enzymes, tamoxifen (TAM) offers a scope for research owing to poor aqueous solubility and compromised bioavailability. The present study designs a novel copolymer derived from palmitic acid and chitosan, and evaluate the derived TAM-loaded micelles for various delivery attributes. The nanometric micellar carriers not only substantially loaded the drug, but also controlled the rate of release of TAM. The designed nanocarrier substantially enhanced the cytotoxicity of TAM on MCF-7 cancer cells. The developed system was designed for intravenous route and was observed to be substantially compatible enhancement of approx. 5 times in AUC vis-a-vis plain drug and the biological half-life was increased by 3 times. The findings employing new polymer-based carrier are promising in nature for the better delivery of similar drugs.
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