One new spirocyclic lactone and one new benzopyran derivative from Aspergillus terreus
2021
Li, Dong-Yan | Han, Pan | Wu, Zhao-Di | Chen, Chun-Mei | Tong, Qing-Yi | Zhu, Hu-Cheng | Guo, Jie-Ru | Lai, Yong-Ji | Zhang, Yong-Hui
One new spirocyclic lactone, terreinlactone C (1), and one new benzopyran derivative, 2,2-dimethyl-3-hydroxychroman-6-aldehyde (2), were discovered from the fungus Aspergillus terreus. The chemical structures of compounds 1 and 2 were elucidated by detailedly analyzing NMR and HRESIMS data. Compound 1 is the first natural product with a 1-oxaspiro[4.5]decan-2-one ring system and a possible biogenetic pathway is proposed. Two compounds were tested for their cytotoxic activities against five human cancer cell lines.
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