A ceRNA Hypothesis: The Rosetta Stone of a Hidden RNA Language?
2011
Salmena, Leonardo | Poliseno, Laura | Tay, Yvonne | Kats, Lev | Pandolfi, Pier Paolo
Here, we present a unifying hypothesis about how messenger RNAs, transcribed pseudogenes, and long noncoding RNAs “talk” to each other using microRNA response elements (MREs) as letters of a new language. We propose that this “competing endogenous RNA” (ceRNA) activity forms a large-scale regulatory network across the transcriptome, greatly expanding the functional genetic information in the human genome and playing important roles in pathological conditions, such as cancer.
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