Inhibitory effects of trans-resveratrol analogs molecules on the proliferation and the cell cycle progression of human colon tumoral cells
2008
Marel, Anna-Kristina | Lizard, Gérard | Izard, Jean-Claude | Latruffe, Norbert | Delmas, Dominique
Resveratrol may function as a cancer chemopreventive agent. However, few data are available on the antitumoral activities of its dimer, ε-viniferin, also present in human diet. So, the effects of resveratrol, ε-viniferin, of their acetylated forms (resveratrol triacetate, ε-viniferin pentaacetate) and of vineatrol (a wine grape extract) were compared on human adenocarcinoma colon cells. Resveratrol and resveratrol triacetate inhibit cell proliferation and arrest cell cycle. ε-Viniferin and ε-viniferin pentaacetate slightly reduce cell proliferation. Vineatrol inhibits cell proliferation and favors an accumulation in the S phase of the cell cycle. Consequently, resveratrol triacetate and vineatrol could constitute new putative anticancer agents on colon carcinoma.
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