Cell-permeable small molecule probes for site-specific labeling of proteins
2004
Yeo, Dawn S. Y. | Srinivasan, Rajavel | Uttamchandani, Mahesh | Chen, Grace Y. J. | Zhu, Qing | Yao, Shao Q.
We have successfully synthesized a number of small molecule probes designed for site-specific labeling of N-terminal cysteine-containing proteins expressed in live cells. Their utility for site-specific, covalent modifications of proteins was successfully demonstrated with purified proteins in vitro, and with live bacterial cells in vivo.
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