Caffeinated and decaffeinated coffee effects on plasma lipoprotein cholesterol, apolipoproteins, and lipase activity: a controlled, randomized trial
1991
Superko, H.R. | Bortz, W. Jr | Williams, P.T. | Albers, J.J. | Wood, P.D.
Coffee consumption has been associated with elevated plasma cholesterol. One hundred eighty-one men consumed a standard caffeinated coffee for 2 mo followed by randomization to continue caffeinated coffee (control), change to decaffeinated coffee or no coffee for 2 mo. Plasma low-density-lipoprotein (LDL) cholesterol and apolipoprotein B concentrations increased significantly (0.12 +/- 0.65 mmol/L, P < 0.025; 0.06 +/- 0.12 g/L, P < 0.0004, respectively) in the group that changed to decaffeinated coffee. In a subgroup (n = 51), postheparin lipoprotein lipase decreased significantly more (-270 mmol free fatty acids .L-1.h-1, P < 0.003) in the decaffeinated coffee group. Resting heart rate and blood pressure did not change significantly. Change from caffeinated to decaffeinated coffee increased plasma LDL cholesterol and apolipoprotein B whereas discontinuation of caffeinated coffee revealed no change. This finding suggests that a coffee component other than caffeine is responsible for the LDL cholesterol, apolipoprotein B, and lipase activity changes reported in this investigation.
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