Leucanone A and naamine J, glycerol ether lipid and imidazole alkaloid from the marine sponge Leucandra sp
2017
Tang, Wei-Zhuo | Yang, Zhong-Zhen | Sun, Fan | Wang, Shu-Ping | Yang, Fan | Lin, Hou-Wen
Chemical investigation on CH ₂Cl ₂ extract of the marine sponge Leucandra sp. afforded two new compounds named leucanone A (1) and naamine J (2), together with eight known compounds (3–10). Their structures were elucidated on the basis of NMR spectroscopic analyses, and comparing with the literature. The cytotoxic activities of the compounds were evaluated against four cancer cell lines, and compound 2 showed mild cytotoxic activities against MCF-7, A549, HeLa, and PC9 cancer cell lines with IC ₅₀ values in the range of 20.1–45.3 μM.
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