Benzimidates as gem-Diamidation and Amidoindolyzation Cascade Synthons with a Hydrated Niᴵᴵ Catalyst
2020
Nandi, Rajesh | Mandal, Prakash K. | Kayet, Anirban | Bhattachariya, Tamalika | Ghosh, Sukla | Maiti, Dilip K.
We contributed a new benzimidate chemistry through moisture-insensitive Niᴵᴵ/Niᴵᴵ-Feᴵᴵᴵ combo-catalysis for a simultaneous 2–3 bond-forming gem-diamidation and amidoindolyzation cascade reaction to construct symmetrical and unsymmetrical gem-(arylmethylene)amides and indolo(arylmethylene)amides, using emerging benzimidate synthons. The operational simplicity, mild nature, generality, and robustness of the strategy were validated through syntheses of a wide range of new molecules, labile sugar-based chiral compounds, and pharmaceuticals with high yields under the same reaction conditions.
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