Inulin–Niacin Conjugates: Preparation, Characterization, Kinetic and In Vitro Release Studies
2022
Ganie, Showkat Ali | Ali, Akbar | Mir, Tariq Ahmad | Mazumdar, Nasreen
Niacin, an essential B-complex vitamin, used in the treatment of nonalcoholic fatty liver disease is the first perceived lipid regulating medication, inhibits and reverses hepatic steatosis and inflammation in animals and liver cell cultures. Niacin shows beneficial effects on adiposity. Niacin plays an important role in DNA repair, electron transfer, one-carbon metabolism and fatty acid synthesis in cells. Natural polysaccharides with desirable chemical modifications can be combined with vitamins for developing the supplement treatment for vitamin deficiency disorders. Modification of inulin was carried out by tosylation, amination and then conjugated with niacin. Structural elucidation of the derivatives and conjugates was carried out by FT-IR, ¹H NMR and SEM. Thermal behavior was investigated by TGA and DSC techniques. The release and kinetics of niacin, from the conjugate, at different pH was studied. The release was observed to be pH dependent, showing a greater release at higher pH following Korsmeyer–Peppas kinetic model. Polysaccharide based approach was used for the preparation of stable niacin-inulin conjugates with controllable and prolonged release of niacin. These types of conjugates may be useful as vitamin delivery systems for vitamin deficiency disorders.
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